The Regulatory Genome: Gene Regulatory Networks In Development And Evolution |  | Author: Eric H. Davidson
Publisher: Academic Press
List Price: $79.95
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Rating:  2 reviews
Sales Rank: 340343
Media: Hardcover
Edition: 1
Pages: 304
Number Of Items: 1
Shipping Weight (lbs): 1.7
Dimensions (in): 9.3 x 7.6 x 0.7
ISBN: 0120885638
Dewey Decimal Number: 572.865
EAN: 9780120885633
ASIN: 0120885638
Publication Date: June 13, 2006
Availability: Usually ships in 1-2 business days
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Product Description
Gene regulatory networks are the most complex, extensive control systems found in nature. The interaction between biology and evolution has been the subject of great interest in recent years. The author, Eric Davidson, has been instrumental in elucidating this relationship. He is a world renowned scientist and a major contributor to the field of developmental biology.
The Regulatory Genome beautifully explains the control of animal development in terms of structure/function relations of inherited regulatory DNA sequence, and the emergent properties of the gene regulatory networks composed of these sequences. New insights into the mechanisms of body plan evolution are derived from considerations of the consequences of change in developmental gene regulatory networks. Examples of crucial evidence underscore each major concept. The clear writing style explains regulatory causality without requiring a sophisticated background in descriptive developmental biology. This unique text supersedes anything currently available in the market.
* The only book in the market that is solely devoted to the genomic regulatory code for animal development
* Written at a conceptual level, including many novel synthetic concepts that ultimately simplify understanding
* Presents a comprehensive treatment of molecular control elements that determine the function of genes
* Provides a comparative treatment of development, based on principles rather than description of developmental processes
* Considers the evolutionary processes in terms of the structural properties of gene regulatory networks
* Includes 42 full-color descriptive figures and diagrams
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| Customer Reviews:
 advanced, difficult, important December 30, 2007
OhioValley (Kentucky)
16 out of 17 found this review helpful
If you really want to understand what is known about DNA transcription, you will first get a 500 level background in cell biology and biochemistry. After reading Genomes 3 by TA Brown (very good) you will hav a 600 level understanding. Now at the 700 level, the reading is tougher and doesn't fit together very well. You will need to read "Epigenetics" by Allis et al, since other authors mostly ignore it and it is important. Next, learn some embryology, which should be in an appendix in Davidson, but isn't.
Now you are ready for Davidson's "The Regulatory Genome." It is difficult and poorly explained. The core material is in multi-page figures with multi-page captions. The combination of no legend for the diagramming conventions, and highly complex biology, will surprise you if you are used to readily-understood biology figures. The transcription regulation discussed is that of embryological development, which is rather different from the metabolic enzyme regulation discussed in cell biology and biochemistry. If you stop struggling with the details in the figures, and hold them at arm's length, you get a glimpse of the essence of developmental biology at the molecular level.
There is much that isn't covered -- heterochromatin, euchromatin, transcription differences between the sexes, the master timing mechanism, the role of noncoding DNA -- but this is the frontier. If you want that glimpse, you should learn the prerequesite material, and THEN read Davidson.
 A real theory of biology and evolution March 22, 2007
P. Calvert (Potomac, MD USA)
15 out of 15 found this review helpful
This book will be a revelation to any biologist who has not been reading the literature on development and embryology attentively. Davidson eloquently articulates a real theory of the mechanism by which the genome computes the embryologic development of bilaterian animals. The argument is carefully developed from simple principles to more complex implications. The figures are a major part of the book's exposition, and repay very careful reading of the legends along with the associated text. The references are as current as 2006, so the book is quite cutting edge in its outlook. I heartily recommend it to any biologically sophisticated reader. It does presume elementary knowledge about biochemistry and molecular biology at about the freshman/sophomore college level. Enjoy!
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